Concentration and Binding Capacity of Thyroxin-binding Prealbumin in Pregnancy, Hyper- and Hypothyroidism

Thyroxine-binding prealbumin in thyrotoxicosis and hypothyroidism.

THYROXINE is reversibly bound in the plasma to three proteins: thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin. Changes in the binding capacities of TBG and TBPA in patients with thyroid disease have been reported previously (1, 2). Since starch-gel electrophoresis of serums of patients with thyrotoxicosis indicated a marked decrease in density of the stain in...

Concentration of free thyroxin in serum of a patient with euthyroid hyperthyroxinemia secondary to increased thyroxin-binding prealbumin: results by various methods compared.

We used various kits to measure free thyroxin (T4) in serum from a patient with the very rare syndrome of euthyroid hyperthyroxinemia secondary to increased thyroxin-binding prealbumin in serum. This patient's free T4 by equilibrium dialysis was 13 ng/L (normal 9-21), whereas the free-T4 index was 18.6 (normal 5.5-11.5). Using six different commercial methods, the last three listed being T4-ana...

Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy

Direct and indirect techniques for free thyroxin compared in patients with nonthyroidal illness. II. Effect of prealbumin, albumin, and thyroxin-binding globulin.

We studied the correlation of thyroxin (T4)-binding proteins with the apparent free T4 (FT4) in 101 patients with nonthyroidal illness (NTI). Most patients (95%) were seriously ill at the time of blood collection. Concentrations of T4-binding prealbumin (transthyretin), albumin, and T4-binding globulin (TBG) often were low in the sera of these patients. Albumin was the most frequently subnormal...

Total iron-binding capacity calculated from serum transferrin concentration or serum iron concentration and unsaturated iron-binding capacity.

in borderline cases. The routine use of other biomar-ker assays, such as HFABP in conjunction with tGST activity, could provide complementary information on the potential allograft " viability ". This is illustrated by the fact that there was better segregation of donor categories (controlled vs uncontrolled) with HFABP than with tGST activity. This finding therefore warrants continued evaluati...